Clinical profile and association of Celiac Disease in children with type-1 Diabetes Mellitus

OBJECTIVE: To find out the clinical profile and association of Celiac Disease (CD) in children with established type-1 Diabetes Mellitus (T1DM) presenting a tertiary care hospital Karachi, Pakistan. METHODS: This cross-sectional study was conducted from January-2019 to July-2019 at National Institute Child Health, A total 126 T1DM patients age 1-18 years were subjected detailed history examination for CD except those diabetic ketoacidosis having pancreatic calcifications. Blood sample drawn Tissue Transglutaminase (tTg) Immunoglobulin (IgA) tTg G (IgG) levels Anti-Deamidated Gliadin Peptide (anti-DGP) IgG estimated using commercially available Enzyme Linked Immunosorbant Assay. RESULTS: Twenty-nine (23.0%) diagnosed as based on positive serology. The mean 9.31±4.40 years, 70 (55.6%) male 56 (44.4%) female. Out patients, 29 CD. Raised anti-DGP observed 39 (30.95%) raised anti-tTg-IgA 35 (27.78%) Anti-tTg level 36 (28.57%) cases. Other associated features included anemia (n=85; 67.46%), vomiting (n=50; 39.6%), abdominal distension (n=37; 29.3%), diarrhea (n=30; 23.81%) pain (n=26; 20.6%). CONCLUSION: is relatively common T1DM, affecting both genders. Specific serological markers proved significant identification. highlights like gastrointestinal symptoms, emphasizing need careful consideration patients.